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Case Reports
. 1999 Dec;94(12):3632-3.
doi: 10.1111/j.1572-0241.1999.01623.x.

Severe cholestasis related to intraconazole for the treatment of onychomycosis

J A Talwalkar  1 , R E Soetikno, D L Carr-Locke, C L Berg
Affiliations
Case Reports

Severe cholestasis related to intraconazole for the treatment of onychomycosis

J A Talwalkar et al. Am J Gastroenterol. 1999 Dec.

Abstract

We describe a case of prolonged cholestasis temporally associated with the use of itraconazole for onychomycosis. Peak bilirubin level of 32.0 mg/dl was documented approximately 2 months after discontinuation of the patient's itraconazole therapy, with symptoms of cholestasis persisting more than 1 month after the peak in bilirubin. Physicians should be aware of the potential for severe cholestasis associated with itraconazole usage.

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