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Case Reports
. 1999 Dec;26(12):2695-7.

Bone non-union after osteotomy in patients treated with methotrexate

J C Gerster  1 , R Bossy, J Dudler
Affiliations
  • PMID: 10606386
Case Reports

Bone non-union after osteotomy in patients treated with methotrexate

J C Gerster et al. J Rheumatol. 1999 Dec.

Abstract

We describe 2 men with seronegative rheumatoid arthritis who presented non-union of bone after osteotomy of the tibia in one case and of a metatarsal bone in the second. Both patients were still being treated with oral low doses of methotrexate (MTX). After MTX was stopped, a prompt healing of the bone occurred. These observations suggest that MTX should be stopped temporarily in cases with delayed bone healing after surgery.

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