Review
doi: 10.1016/s0959-437x(99)00023-4.
The minimal genome concept
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- PMID: 10607608
- DOI: 10.1016/s0959-437x(99)00023-4
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Review
The minimal genome concept
Curr Opin Genet Dev.
1999 Dec.
Abstract
Complete genome sequences are becoming available for a large number of diverse species. Quantification of gene content, of gene family expansion, of orthologous gene conservation, as well as their displacement, are now possible - laying the ground for the estimation of the minimal set of proteins sufficient for cellular life. The consensus of computational results suggests a set close to 300 genes. These predictions will be evaluated by engineering of small bacterial genomes.
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