Review
doi: 10.1016/s1369-5274(99)00030-2.
Altered states: programmed proteolysis and the budding yeast cell cycle
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- PMID: 10607629
- DOI: 10.1016/s1369-5274(99)00030-2
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Review
Altered states: programmed proteolysis and the budding yeast cell cycle
Curr Opin Microbiol.
1999 Dec.
Abstract
The recent identification of an essential RING-H2 finger protein in the SCF E3 ubiquitin ligase complex of budding yeast has uncovered a family of related E3 enzymes, including the other main cell cycle E3 complex, the anaphase promoting complex (APC). Recent insights into APC-dependent proteolysis include a novel protease activity that dissolves cohesion between sister chromatids at anaphase, and a crucial phosphatase, Cdc14, whose release from the nucleolus eliminates cyclin-dependent kinase activity and thereby drives exit from mitosis.
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