Review
doi: 10.1016/s0959-440x(99)00030-5.
Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II
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- PMID: 10607668
- DOI: 10.1016/s0959-440x(99)00030-5
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Review
Novel ways to prevent proteolysis - prophytepsin and proplasmepsin II
Curr Opin Struct Biol.
1999 Dec.
Abstract
The recently determined crystal structures of two aspartic proteinase zymogens, prophytepsin from barley and proplasmepsin II from the malarial parasite Plasmodium falciparum, have provided new insights into zymogen inactivation. Prophytepsin shows a variation of the mechanism of inhibition used by the well-known gastric aspartic proteinase zymogens, whereas proplasmepsin II uses a completely new mode of inactivation.
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