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Review
. 1999 Dec;9(6):738-44.
doi: 10.1016/s0959-440x(99)00038-x.

Cyclin-dependent kinases: inhibition and substrate recognition

J A Endicott  1 , M E Noble, J A Tucker
Affiliations
Review

Cyclin-dependent kinases: inhibition and substrate recognition

J A Endicott et al. Curr Opin Struct Biol. 1999 Dec.

Abstract

Four unresolved issues of cyclin-dependent kinase (CDK) regulation have been addressed by structural studies this year - the mechanism of CDK inhibition by members of the INK4 family of CDK inhibitors, consensus substrate sequence recognition by CDKs, the role of the cyclin subunit in substrate recognition and the structural mechanism underlying CDK inhibition by phosphorylation.

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