doi: 10.1016/s0028-3908(99)00109-4.
MTSEA potentiates 5-HT3 receptors containing the nicotinic alpha4 subunit
Affiliations
- PMID: 10608286
- DOI: 10.1016/s0028-3908(99)00109-4
Item in Clipboard
MTSEA potentiates 5-HT3 receptors containing the nicotinic alpha4 subunit
Neuropharmacology.
1999 Dec.
Abstract
In order to study the subunit composition of 5-HT3 receptors (5-HT3R), we report that (2-aminoethyl)methanethiosulfonate (MTSEA) can enhance the function of both nicotinic ACh receptors (nAChRs) comprised of alpha4/beta2 subunits, and heteromeric channels assembled from serotonin 5-HT3R and alpha4 nAChR subunits. MTSEA has no effect on homomeric 5-HT3 receptor channels.
Similar articles
-
Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterization.J Physiol. 2002 Nov 1;544(3):715-26. doi: 10.1113/jphysiol.2002.029736. J Physiol. 2002. PMID: 12411518 Free PMC article.
-
The nicotinic alpha4 receptor subunit contributes to the lining of the ion channel pore when expressed with the 5-HT3 receptor subunit.J Biol Chem. 1999 Feb 12;274(7):3934-6. doi: 10.1074/jbc.274.7.3934. J Biol Chem. 1999. PMID: 9933581
-
Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channels.Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11456-61. doi: 10.1073/pnas.95.19.11456. Proc Natl Acad Sci U S A. 1998. PMID: 9736758 Free PMC article.
-
The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance.Biochem Soc Trans. 2004 Jun;32(Pt3):547-52. doi: 10.1042/BST0320547. Biochem Soc Trans. 2004. PMID: 15157181 Review.
-
The 5-HT(3) and nACh ionotropic receptors: a perspective from the computational chemistry point of view.Curr Med Chem. 2002 Jan;9(1):99-125. doi: 10.2174/0929867023371328. Curr Med Chem. 2002. PMID: 11860352 Review.
Cited by
-
Serotonin 5-HT(3) receptors in rat CA1 hippocampal interneurons: functional and molecular characterization.J Physiol. 2002 Nov 1;544(3):715-26. doi: 10.1113/jphysiol.2002.029736. J Physiol. 2002. PMID: 12411518 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
