Techniques for mechanical stimulation of cells in vitro: a review

Abstract

A wide variety of laboratory apparatuses have been devised for mechanical stimulation of cell and tissue cultures. This article reviews the functional attributes of several dozen systems developed for that purpose, including their major advantages and disadvantages. These devices can be categorized in terms of their primary loading modality: compression (hydrostatic pressure or direct platen contact), longitudinal stretch, bending, axisymmetric substrate bulge, in-plane substrate distention, fluid shear stress, or combined substrate distention and fluid shear.