doi: 10.1073/pnas.72.12.4825.
X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA
- PMID: 1061071
- PMCID: PMC388824
- DOI: 10.1073/pnas.72.12.4825
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X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA
Proc Natl Acad Sci U S A.
1975 Dec.
Abstract
Good quality x-ray diffraction patterns have been obtained of polycrystalline fibers containing 2-hydroxyethanethiolato(2,2'2"-terpyridine)platinum(II) bound to calf thymus DNA by intercalation. The photographs strongly support the neighbor exclusion binding model in which electron-dense platinum atoms are regularly distributed at 10.2 A intervals, every other interbase pair site.
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