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. 1975 Dec;72(12):4825-9.
doi: 10.1073/pnas.72.12.4825.

X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA

P J Bond, R Langridge, K W Jennette, S J Lippard

X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA

P J Bond et al. Proc Natl Acad Sci U S A. 1975 Dec.

Abstract

Good quality x-ray diffraction patterns have been obtained of polycrystalline fibers containing 2-hydroxyethanethiolato(2,2'2"-terpyridine)platinum(II) bound to calf thymus DNA by intercalation. The photographs strongly support the neighbor exclusion binding model in which electron-dense platinum atoms are regularly distributed at 10.2 A intervals, every other interbase pair site.

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