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. 1999 Dec 21;96(26):14672-4.
doi: 10.1073/pnas.96.26.14672.

Ig-like domains: evolution from simple interaction molecules to sophisticated antigen recognition

A N Barclay  1
Affiliations

Ig-like domains: evolution from simple interaction molecules to sophisticated antigen recognition

A N Barclay. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
Blob diagram to illustrate various proteins containing IgSF domains, including the antigen receptors. The IgSF domains are illustrated by open circles and marked V, C1, or C2 according to sequence patterns and size (7). The lollipop symbols indicate the approximate position of N-linked glycosylation sites. The arrow in Thy-1 indicates the presence of a glycosyl-phosphatidylinositol anchor. The protein data for Thy-1, Ig, TcR, CD2, and OX2 are from ref. , the NITR from Strong et al. (1) and CTX from ref. .
Figure 2
Figure 2
The Ig fold. (A) Ribbon diagram of the x-ray crystallography structure of the heavy chain V region of human myeloma New (Protein Database 7fab). (B) Schematic representation of the strands that form the two sheets of the fold. In both A and B the ABED sheet is colored blue and the GFCC′C" sheet is green. The three loops that make up the hypervariable regions are indicated in red. (C) Linear representation of the strands in B. Note C domains lack the extra loops C′ and C". C2 domains lack the C" strand. (D) Scheme for the generation of individual TcRβ or heavy chains whereby particular V region, D and J segments are selected and recombined to form a VDJ segment. After transcription the introns are spliced out to give the full mRNA. Further exons coding for C regions and transmembranes are not included for simplicity.
See this image and copyright information in PMC

Comment in

  • A novel multigene family encodes diversified variable regions.
    Strong SJ, Mueller MG, Litman RT, Hawke NA, Haire RN, Miracle AL, Rast JP, Amemiya CT, Litman GW. Strong SJ, et al. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15080-5. doi: 10.1073/pnas.96.26.15080. Proc Natl Acad Sci U S A. 1999. PMID: 10611341 Free PMC article.

References

    1. Strong S J, Mueller M G, Litman R T, Hawke N A, Haire R N, Miracle A L, Rast J P, Amemiya C T, Litman G W. Proc Natl Acad Sci USA. 1999;96:15080–15085. - PMC - PubMed
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