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Comment
. 2000 Jan;115(1):29-32.
doi: 10.1085/jgp.115.1.29.

Structure and packing orientation of transmembrane segments in voltage-dependent channels. Lessons from perturbation analysis

E Perozo  1
Affiliations
Comment

Structure and packing orientation of transmembrane segments in voltage-dependent channels. Lessons from perturbation analysis

E Perozo. J Gen Physiol. 2000 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Comparison of Trp scanning mutagenesis in Shaker channels with Ala scanning mutagenesis in drk1 channels for transmembrane segments S1, S2, and S3. Stretches of 23 residues including each transmembrane segment were aligned, and the high-impact positions for each mutagenesis scan annotated in a helical wheel projection. The orientation of each helical wheel is referred in each case to the first position in the alignment (right-most position in the wheel). High-impact positions from the Trp scan are labeled with a circled W, and those from the Ala scan with a circled A. Positions in which both data sets coincide are labeled with a check mark. The continuous line points to the proposed lipid exposed surface for each segment.
See this image and copyright information in PMC

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References

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