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Comment
. 2000 Jan 3;191(1):1-4.
doi: 10.1084/jem.191.1.1.

Genetically linked scientists. The one-two punch for NFATp knockout

A I Caplan  1 , J E Dennis
Affiliations
Comment

Genetically linked scientists. The one-two punch for NFATp knockout

A I Caplan et al. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
The mesengenic process. MSCs have the potential to differentiate into a variety of mesenchymal tissues, such as bone, cartilage, tendon, muscle, marrow, fat, and dermis. Proliferating MSCs enter a lineage after their commitment to that particular pathway. The commitment event involves the action of specific growth factors and/or cytokines, as does the next phase in which the lineage-committed cells progress through several transitory stages in the lineage progression process. Terminal differentiation involves the cessation of proliferation and the massive biosynthesis of tissue-specific products, usually highly site-specific extracellular matrix. Finally, these differentiated cells go through a maturation stage in which they acquire an ability to function in aspects of tissue homeostasis as opposed to high levels of synthetic activity. All of these end stage–differentiated cells have fixed half-lives and can be expected to expire; these cells are replaced by newly differentiated cells arising from the continuous transition down the lineage pathway (reproduced from reference 20).
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References

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