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Comment
. 2000 Jan 3;191(1):5-8.
doi: 10.1084/jem.191.1.5.

The development of B cells in the bone marrow is controlled by the balance between cell-autonomous mechanisms and signals from the microenvironment

R Carsetti  1
Affiliations
Comment

The development of B cells in the bone marrow is controlled by the balance between cell-autonomous mechanisms and signals from the microenvironment

R Carsetti. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
The interplay between IL-7 and the pre-BCR in the bone marrow. Stromal cells produce and release IL-7. Pro-B cells of fraction A (green) express the IL-7R, and their Ig H chain genes are in germline or DH-JH configuration. VH→DHJH rearrangement is induced in pro-/pre-B I cells of fraction B–C after an IL-7–generated signal (red). At the large pre-B II cell stage, the expression of the pre-BCR generates a constitutive signal (blue), which is integrated with the signal induced by IL-7 (red). Pre-B cells progressively lose the contact to stromal cells and downregulate the IL-7R. At this point, they exclusively depend on the pre-BCR for the last phases of development. Immature B cells (light gray) express a complete BCR. The top line represents the B cell developmental pathway in normal mice. The color code indicates the developmental phases that depend on IL-7 (red) or on the BCR (blue). The other lines show the developmental block seen in mutant mice. The thin blue line shows that in the indicated mutant mice pre-BCR–dependent development can proceed, but without extensive proliferation.
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Comment on

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