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. 1999 Dec 24;277(2):134-6.
doi: 10.1016/s0304-3940(99)00859-9.

5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa

B Nacmias  1 , V Ricca, A Tedde, B Mezzani, C M Rotella, S Sorbi
Affiliations

5-HT2A receptor gene polymorphisms in anorexia nervosa and bulimia nervosa

B Nacmias et al. Neurosci Lett. .

Abstract

To examine the distribution of different polymorphisms in genes of the 5-HT system in patients with anorexia nervosa (AN) and bulimia nervosa (BN), we analyzed the distribution of a polymorphism (-1438G/A) and the presence of known mutations in 5-HT2A and 5-HT2C receptor genes in 168 Italian female patients affected by AN and BN. Patients with AN restricting type (ANr) only, unlike those with AN binge eating/purging type (ANp) and BN purging type (BNp), showed a statistically significant difference in 5-HT2A-1438A/A genotype frequency with respect to controls. With regard to the other polymorphisms, no differences were found in the studied groups with respect to controls. 5-HT2A promoter polymorphism is probably implicated in the susceptibility to eating disorders and its involvement is more significant in ANr, when compared with ANp and BNp.

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