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. 1976 Feb;56(2):445-6.
doi: 10.1093/jnci/56.2.445.

Induction of malignant bone tumors in rats by 1-(2-hydroxyethyl)-1-nitrosourea

A Pelfrene, S S Mirvish, B Gold

Induction of malignant bone tumors in rats by 1-(2-hydroxyethyl)-1-nitrosourea

A Pelfrene et al. J Natl Cancer Inst. 1976 Feb.

Abstract

Forty male MRC-W rats were treated chronically with 1-(2-hydroxyethyl)-1-nitrosourea in drinking water (total dose, 330 mg/rat). Fifteen rats (38%) developed osteogenic osteosarcomas or chondrosarcomas of the lower vertebrae. This was the first time that an orally administered organic compound induced a high incidence of these tumors.

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