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. 2000 Jan;45(1):9-13.
doi: 10.1093/jac/45.1.9.

Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

O Ciofu  1 , T J Beveridge, J Kadurugamuwa, J Walther-Rasmussen, N Høiby
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Chromosomal beta-lactamase is packaged into membrane vesicles and secreted from Pseudomonas aeruginosa

O Ciofu et al. J Antimicrob Chemother. 2000 Jan.

Abstract

Membrane vesicles were isolated from one beta-lactam-sensitive and three beta-lactam-resistant Pseudomonas aeruginosa clinical isolates from patients with cystic fibrosis. The presence of the chromosomally encoded beta-lactamase in the membrane vesicles was shown by electron microscopy and enzymatic studies. This is the first report of extracellular secretion of beta-lactamase in P. aeruginosa and it seems that the enzyme is packaged into membrane vesicles.

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