[Effectiveness of mesoglycan topical treatment of leg ulcers in subjects with chronic venous insufficiency]

Abstract

Background: Aim of the present comparative clinical study was to demonstrate the efficacy of the topical application of mesoglycan, a profibrinolytic agent, for healing of leg ulcers in patients with chronic venous insufficiency.

Methods: Forty patients, observed in our outpatients department, with venous leg ulcers have been randomized in two groups of twenty subjects, each treated with topical application of mesoglycan (1 or 2 vials/day) or vegetal stimulins and followed for two months, with controls after 15, 30 and 60 days.

Results: At the end of the observation period, ulcer healing rate was 95% in the mesoglycan group, while a lower healing rate was obtained in the stimulins group (80%).

Conclusions: The present study confirms previous clinical experiences with mesoglycan and suggests its application in the topical treatment of venous ulcers.