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Review
. 1999 Dec;6(12):R319-25.
doi: 10.1016/s1074-5521(00)80001-0.

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

D E Cane  1 , C T Walsh
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Review

The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases

D E Cane et al. Chem Biol. 1999 Dec.

Abstract

Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) catalyze chain elongation from simple building blocks to create a diverse array of natural products. PKS and NRPS proteins share striking architectural and organizational similarities that can be exploited to generate entirely new natural products.

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