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. 1976 Apr;73(4):1279-83.
doi: 10.1073/pnas.73.4.1279.

Influence of diet on survival of mice

Influence of diet on survival of mice

G Fernandes et al. Proc Natl Acad Sci U S A. 1976 Apr.

Abstract

The longevity of mice of the (NZB X NZW)F1 (B/W) strain and the DBA/2f strain of mice is dramatically prolonged by dietary restriction. B/W mice are susceptible to, and die at an early age from, immunocomplex nephritis. Mice of the DBA/2f strain are also relatively short-lived. Restriction of caloric intake prolonged life of B/W mice more than did protein restriction. DBA/2f mice showed prolongation of life when the diet was restricted only with respect to protein. Caloric restriction alone prolonged life less in DBA/2f mice than in B/W mice. These observations show that dietary manipulations have profound effects on immunity functions, including inhibition of the development of life-shortening autoimmune disease.

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References

    1. Curr Top Microbiol Immunol. 1974;64(0):79-103 - PubMed
    1. Am J Clin Nutr. 1974 Jun;27(6):647-64 - PubMed
    1. Cancer Res. 1973 Apr;33(4):807-12 - PubMed
    1. Mech Ageing Dev. 1973 Dec-1974 Feb;2(6):447-54 - PubMed
    1. Lab Invest. 1973 Sep;29(3):278-81 - PubMed

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