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Clinical Trial
. 2000 Jan;82(1):F14-8.
doi: 10.1136/fn.82.1.f14.

Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome

M W Beresford  1 , N J Shaw, D Manning
Affiliations
Clinical Trial

Randomised controlled trial of patient triggered and conventional fast rate ventilation in neonatal respiratory distress syndrome

M W Beresford et al. Arch Dis Child Fetal Neonatal Ed. 2000 Jan.

Abstract

Aim: To compare patient triggered, with conventional fast rate, ventilation in a randomised controlled trial using the incidence of chronic lung disease as the primary outcome measure.

Methods: Three hundred and eighty six preterm infants with birthweights from 1000 to 2000 g, and requiring ventilation for respiratory distress syndrome within 24 hours of birth, were randomised to receive either conventional or trigger ventilation with the SLE 2000 ventilator.

Results: There were no significant differences in the incidence of chronic lung disease (28 day and 36 week definitions), death, pneumothorax, intraventricular haemorrhage, number of ventilator days, or length of oxygen dependency between groups.

Conclusions: Patient triggered ventilation in preterm infants with respiratory distress syndrome is feasible. No significant differences, when compared with conventional fast rate ventilation in important medium and longer term outcome measures, were evident.

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Comment in

  • Mechanical ventilation of the newborn.
    Mammel MC. Mammel MC. Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F224. doi: 10.1136/fn.83.3.f224. Arch Dis Child Fetal Neonatal Ed. 2000. PMID: 11203241 Free PMC article. No abstract available.
  • PTV: should it be patient triggered and patient terminated ventilation?
    Visveshwara N. Visveshwara N. Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F224-5; author reply F225. doi: 10.1136/fn.83.3.f224a. Arch Dis Child Fetal Neonatal Ed. 2000. PMID: 11203242 Free PMC article. No abstract available.
  • To trigger or not to trigger?
    Yadav M. Yadav M. Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F225. doi: 10.1136/fn.83.3.f224b. Arch Dis Child Fetal Neonatal Ed. 2000. PMID: 11203243 Free PMC article. No abstract available.
  • Patient triggered ventilation.
    Donn SM, Greenough A, Sinha SK. Donn SM, et al. Arch Dis Child Fetal Neonatal Ed. 2000 Nov;83(3):F225-6. doi: 10.1136/fn.83.3.f224c. Arch Dis Child Fetal Neonatal Ed. 2000. PMID: 11203244 Free PMC article. No abstract available.

References

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    1. J Pediatr. 1996 Apr;128(4):453-63 - PubMed
    1. Arch Dis Child Fetal Neonatal Ed. 1995 May;72(3):F188-90 - PubMed
    1. J Pediatr. 1995 Mar;126(3):407-11 - PubMed
    1. Lancet. 1984 Jan 7;1(8367):1-3 - PubMed

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