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Clinical Trial
. 1976 Jun;33(2):179-88.
doi: 10.1111/j.1365-2141.1976.tb03529.x.

Analysis of treatment in childhood leukaemia. II. Timing and the toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy

I C MacLennan, H E Kay, M Festenstein, P G Smith
Clinical Trial

Analysis of treatment in childhood leukaemia. II. Timing and the toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy

I C MacLennan et al. Br J Haematol. 1976 Jun.

Abstract

The first and second Medical Research Council UKALL trials have shown that alteration in the timing of methotrexate and 6-mercaptopurine maintenance therapy for the treatment of acute lymphoblastic leukaemia can markedly change drug induced toxicity. Maintenance chemotherapy in both trials used a similar total dosage of these drugs but the timing of their administration was different in the two schedules.

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