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Review
. 1999 Sep;8(3):263-78.
doi: 10.1177/096228029900800306.

Clinical cross-over trials in phase I

S Senn  1 , F Ezzet
Affiliations
Review

Clinical cross-over trials in phase I

S Senn et al. Stat Methods Med Res. 1999 Sep.

Abstract

We review the role of cross-over trials in pharmacokinetic and pharmacodynamic studies, in particular as applied in phase I. Design and analysis considerations are covered. We also consider the use of pharmacokinetic and pharmacodynamic theories in planning cross-over trials. Finally some practical considerations are covered.

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