Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Dec 11;354(9195):2053-4.
doi: 10.1016/S0140-6736(99)04805-9.

Inverse relation between prostate-specific antigen and insulin-like growth factor-binding protein 3 in bone metastases and serum of patients with prostate cancer

G L Smith, A P Doherty, H Mitchell, I W Hanham, T J Christmas, R J Epstein

Inverse relation between prostate-specific antigen and insulin-like growth factor-binding protein 3 in bone metastases and serum of patients with prostate cancer

G L Smith et al. Lancet. .

Abstract

The usual osteoblastic phenotype of metastatic prostate cancer is unexplained. Here we show that tissue and serum concentrations of prostate-specific antigen (PSA)-vary inversely with a substrate protein that binds a growth factor known to activate osteoblasts. These findings suggest that PSA may contribute to the osteoblastic phenotype, and could thus represent a new drug target devoid of antiandrogenic toxicity.

PubMed Disclaimer

Comment in

  • Regulatory mechanisms in prostate cancer.
    Jefferson K, Dwivedi A, Persad R, Holly J. Jefferson K, et al. Lancet. 2000 Mar 25;355(9209):1100-1. doi: 10.1016/S0140-6736(05)72223-6. Lancet. 2000. PMID: 10744117 No abstract available.
  • Prostate cancer screening.
    Mannello F, Gazzanelli G. Mannello F, et al. Lancet. 2001 Apr 14;357(9263):1202. doi: 10.1016/S0140-6736(00)04343-9. Lancet. 2001. PMID: 11379564 No abstract available.

Substances