A comparison of three ultrasound estimates of intrapartum oligohydramnios for prediction of fetal hypoxia-reperfusion injury

Abstract

A prospective observational study assessed the predictive value of three techniques for amniotic fluid volume assessment on umbilical cord arterial lipid peroxide levels and acid-base balance. Women with singleton, term, cephalic presentation, and an initially normal fetal heart rate tracing were recruited. All pregnancies had the largest vertical pocket (LVP), two diameter pocket (2phi), and amniotic fluid index (AFI) assessments before and after amniotomy and cord arterial acid-base and lipid peroxide determinations at delivery. In 171 cases with confirmed cord arterial samples, malondialdehyde (MDA), organic hydroperoxide (OHP), pH and base excess (BE) were examined in relationship to intrapartum LVP, 2phi and AFI before and after amniotomy. Improvements in correlation between the estimates of amniotic fluid volume and outcome measures were observed 30 min after amniotomy, particularly with lipid peroxide measurements. Examination of scatter-plots using Lowess regression suggested that the correlation was only valid in cases of oligohydramnios but that the cutoff values recommended in the literature for defining oligohydramnios were not appropriate in our population sample. We suggest that oligohydramnios should be defined as an AFI < 8 cm or LVP < 4 cm. We concur with the recommendation of < 15 cm2 for the 2phi measurement.