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Review
. 2000 Jan 17;191(2):201-6.
doi: 10.1084/jem.191.2.201.

Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells

P Lane  1
Affiliations
Review

Role of OX40 signals in coordinating CD4 T cell selection, migration, and cytokine differentiation in T helper (Th)1 and Th2 cells

P Lane. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic representation of (A) immune responses evoked by protein antigens that do not promote IL-12 in DCs and (B) immune responses (e.g., bacteria) that do. (A) Antigen-activated CD4 T cells are initially costimulated through CD28 by CD86 expressed on DCs 1. This CD28 signal upregulates (yellow arrow indicates intracellular signals) OX40 (red color indicates CD28 dependence). Activated CD4 T cells express CD40L 2 and activate DCs (yellow arrow) to express OX40L (blue color indicates CD40L dependence). Synergistic costimulation through CD28 and OX40 leads to rapid expansion of CD4 T cells on the basis of their ability to recognize antigen presented by DCs (green color). These CD4 cells upregulate expression of the cytokine IL-4 and the chemokine CXCR-5, and CD4 T cells migrate to B follicles to foster GCs. (B) The situation is identical for inflammatory antigens, except that CD4 T cells are signaled by IL-12 (4; black color) in addition to CD28 1. These antigens generate CD4 cells that help both antibody and inflammatory responses, perhaps because IL-12 upregulates inflammatory chemokine receptors. Whether an individual CD4 T cells becomes committed to help B cells or inflammatory responses may depend on the strength of the signal through OX40L 3. This model predicts that high-affinity CD4 cells are selected to migrate to B follicles. If CD4 cells express inflammatory chemokines, they migrate into the bloodstream, where OX40L on vascular endothelium directs their migration into tissue 3.
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