Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2000 Jan;25(1):15-9.
doi: 10.1016/s0968-0004(99)01516-9.

The many HATs of transcription coactivators

C E Brown  1 , T Lechner, L Howe, J L Workman
Affiliations
Review

The many HATs of transcription coactivators

C E Brown et al. Trends Biochem Sci. 2000 Jan.

Abstract

Histone acetylation is closely linked to gene transcription. The identification of histone acetyltransferases (HATs) and the large multiprotein complexes in which they reside has yielded important insights into how these enzymes regulate transcription. The demonstration that HAT complexes interact with sequence-specific activator proteins illustrates how these complexes target specific genes. In addition to histones, some HATs can acetylate non-histone proteins suggesting multiple roles for these enzymes.

PubMed Disclaimer

Publication types

LinkOut - more resources