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. 2000 Feb;44(2):433-6.
doi: 10.1128/AAC.44.2.433-436.2000.

Mechanisms of resistance to quinupristin-dalfopristin among isolates of Enterococcus faecium from animals, raw meat, and hospital patients in Western Europe

M Soltani  1 , D Beighton, J Philpott-Howard, N Woodford
Affiliations

Mechanisms of resistance to quinupristin-dalfopristin among isolates of Enterococcus faecium from animals, raw meat, and hospital patients in Western Europe

M Soltani et al. Antimicrob Agents Chemother. 2000 Feb.

Abstract

Twenty-eight quinupristin-dalfopristin-resistant isolates of Enterococcus faecium from hospital patients and nonhuman sources in European countries were studied. High-level resistance (MICs, >/=32 microg/ml) was associated with the presence of vat(E) (satG) (14 isolates ¿50%) or vat(D) (satA) (6 isolates ¿21%). These genes were not detected in eight (29%) isolates with lower levels of quinupristin-dalfopristin resistance (MICs, 4 to 16 microg/ml). This suggests the presence of further mechanisms of resistance to quinupristin-dalfopristin in E. faecium.

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