Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2000 Jan;82(2):488-91.
doi: 10.1054/bjoc.1999.0947.

Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance

H Lage  1 , H Helmbach, M Dietel, D Schadendorf
Affiliations

Modulation of DNA topoisomerase II activity and expression in melanoma cells with acquired drug resistance

H Lage et al. Br J Cancer. 2000 Jan.

Abstract

The role of DNA topoisomerases (Topo) IIalpha and IIbeta was investigated in various drug-resistant melanoma cells. Melanoma cells resistant to etoposide, exhibited an up to tenfold reduced Topo II activity corresponding to an increasing degree of drug resistance indicating that modulation of Topo II activity contribute to the drug-resistant phenotype. The reduction of Topo II activity was reflected by decreased nuclear amounts of both Topo II isoforms.

PubMed Disclaimer

References

    1. Cancer Res. 1991 Aug 1;51(15):3951-7 - PubMed
    1. Cancer Res. 1991 Feb 15;51(4):1078-85 - PubMed
    1. Cancer Res. 1993 Mar 15;53(6):1373-9 - PubMed
    1. J Cell Physiol. 1993 May;155(2):414-25 - PubMed
    1. Biochemistry. 1994 Sep 20;33(37):11327-32 - PubMed

Publication types

Associated data