Editorial
doi: 10.1136/heart.83.2.127.
Homocysteine, B vitamins, and risk of cardiovascular disease
- PMID: 10648479
- PMCID: PMC1729293
- DOI: 10.1136/heart.83.2.127
Item in Clipboard
Editorial
Homocysteine, B vitamins, and risk of cardiovascular disease
Heart.
2000 Feb.
No abstract available
Figures
Pathways for the metabolism of homocysteine. Normal transsulfuration requires cystathionine β synthase with vitamin B6 as cofactor. Remethylation requires 5, 10-methylenetetrahydrofolate reductase and methionine synthase. The latter requires folate as cosubstrate and vitamin B12 (cobalamin) as cofactor. An alternative remethylation pathway also exists using the cobalamin independent betaine-homocysteine methyltransferase.
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