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. 2000 Jan;63(1):79-85.
doi: 10.1021/np9903494.

Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis

K D Wellington  1 , R C Cambie, P S Rutledge, P R Bergquist
Affiliations

Chemistry of sponges. 19. Novel bioactive metabolites from Hamigera tarangaensis

K D Wellington et al. J Nat Prod. 2000 Jan.

Abstract

Seven new compounds (1-6 and 10) with a unique carbon skeleton have been isolated from the sponge Hamigera tarangaensis, and the structure of a previously reported metabolite has been revised from 12 to 8. The structures have been assigned from extensive NMR examination. Compounds 3-6 showed moderate in-vitro cytotoxicity against P-388, while 3 showed 100% in-vitro virus inhibition against both the Herpes and Polio viruses, with only slight cytotoxicity.

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