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. 2000 Jan;63(1):149-51.
doi: 10.1021/np9903954.

A cytotoxic 5alpha,8alpha-epidioxysterol from a soft coral Sinularia species

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A cytotoxic 5alpha,8alpha-epidioxysterol from a soft coral Sinularia species

J H Sheu et al. J Nat Prod. 2000 Jan.

Abstract

A new sterol, (22R,23R,24R)-5alpha,8alpha-epidioxy-22, 23-methylene-24-methylcholest-6-en-3beta-ol (1), as well as two known sterols, numersterol A (2) and pregnenolone (3), have been isolated from a soft coral Sinularia sp. The structure of metabolite 1 was determined by spectral analysis. Cytotoxicity of sterols 1-3 toward various cancer cell lines is also reported.

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