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Review
. 2000 Feb;21(2):78-82.
doi: 10.1016/s0167-5699(99)01552-2.

Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases

P P Tak  1 , N J Zvaifler, D R Green, G S Firestein
Affiliations
Review

Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases

P P Tak et al. Immunol Today. 2000 Feb.

Abstract

Oxidative stress at sites of chronic inflammation can cause permanent genetic changes. The development of mutations in the p53 tumor suppressor gene and other key regulatory genes could help convert inflammation into chronic disease in rheumatoid arthritis and other inflammatory disorders.

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