Review
doi: 10.1016/s0962-8924(99)01699-2.
Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors
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- PMID: 10652516
- DOI: 10.1016/s0962-8924(99)01699-2
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Review
Turning on ARF: the Sec7 family of guanine-nucleotide-exchange factors
Trends Cell Biol.
2000 Feb.
Abstract
ARF proteins are important regulators of membrane dynamics and protein transport within the eukaryotic cell. The Sec7 domain is approximately 200 amino acids in size and stimulates guanine-nucleotide exchange on members of the ARF class of small GTPases. The members of one subclass of Sec7-domain proteins are direct targets of the secretion-inhibiting drug brefeldin A, which blocks the exchange reaction by trapping a reaction intermediate in an inactive, abortive complex. A separate subclass of Sec7-domain proteins is involved in signal transduction and possess a domain that mediates membrane binding in response to extracellular signals.
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