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Comment
. 2000 Feb;24(2):101-2.
doi: 10.1038/72730.

A bird's eye view of global methylation

C Eng, J G Herman, S B Baylin
Comment

A bird's eye view of global methylation

C Eng et al. Nat Genet. 2000 Feb.

Abstract

Restriction landmark genomic scanning applied to a broad variety of cancer types can disclose tumour-specific and tumour-type-specific global methylation profiles. This and other genome-scanning approaches allows the rapid analysis of methylation profiles of thousands of genes in parallel-and promises to identify new genes critical to carcinogenesis and other biological processes.

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Comment on

  • Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.
    Costello JF, Frühwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, Wright FA, Feramisco JD, Peltomäki P, Lang JC, Schuller DE, Yu L, Bloomfield CD, Caligiuri MA, Yates A, Nishikawa R, Su Huang H, Petrelli NJ, Zhang X, O'Dorisio MS, Held WA, Cavenee WK, Plass C. Costello JF, et al. Nat Genet. 2000 Feb;24(2):132-8. doi: 10.1038/72785. Nat Genet. 2000. PMID: 10655057

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