Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2000 Feb;24(2):103-4.
doi: 10.1038/72734.

Pushing the envelope on lipodystrophy

J S Flier
Comment

Pushing the envelope on lipodystrophy

J S Flier. Nat Genet. 2000 Feb.

Abstract

Autosomal dominant partial lipodystrophy (PLD), in which regional adipose loss is coupled with insulin resistance, is strongly associated with missense mutations in LMNA, encoding lamin A/C-a component of the nuclear envelope. This finding indicates that other proteins and functions of the nuclear envelope may have bearing on disorders of adipose tissue and insulin action.

PubMed Disclaimer

Comment on

  • LMNA, encoding lamin A/C, is mutated in partial lipodystrophy.
    Shackleton S, Lloyd DJ, Jackson SN, Evans R, Niermeijer MF, Singh BM, Schmidt H, Brabant G, Kumar S, Durrington PN, Gregory S, O'Rahilly S, Trembath RC. Shackleton S, et al. Nat Genet. 2000 Feb;24(2):153-6. doi: 10.1038/72807. Nat Genet. 2000. PMID: 10655060

LinkOut - more resources