[Current approaches to the diagnosis and correction of atherogenic disorders in flight personnel]

Abstract

The review demonstrates the importance of diagnosing early forms of atherosclerotic disorders in pilots. A particular attention has been given to hyperlipidemia as the leading risk factor accompanied by accumulation of atherogenic lipoproteins in blood. Underlying mechanisms have been analyzed, normal contents of main lipids in blood in various age groups were outlined. Discussed are various outlooks on the diagnostic significance of hyperlipidemias, and a principally new method of calculating the professional biological age. The relation between blood levels of lipids and other immunobiochemical indices has been traced. All round consideration is given to status of the immune system as well as changes preceding and attendant to atherosclerosis, and the role of lipid peroxidation in atherogenesis. The necessity to correct disorders in lipid metabolism with, specifically, dietary measures, pharmacological correction and non-medicinal therapy has been demonstrated. Application of of corrective measures depending on the severity of atherosclerosis is substantiated.