Review
doi: 10.1590/s0100-879x2000000200014.
Alternative mitochondrial functions in cell physiopathology: beyond ATP production
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- PMID: 10657067
- DOI: 10.1590/s0100-879x2000000200014
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Review
Alternative mitochondrial functions in cell physiopathology: beyond ATP production
Braz J Med Biol Res.
2000 Feb.
Free article
Abstract
It is well known that mitochondria are the main site for ATP generation within most tissues. However, mitochondria also participate in a surprising number of alternative activities, including intracellular Ca2+ regulation, thermogenesis and the control of apoptosis. In addition, mitochondria are the main cellular generators of reactive oxygen species, and may trigger necrotic cell death under conditions of oxidative stress. This review concentrates on these alternative mitochondrial functions, and their role in cell physiopathology.
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