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. 2000 Feb;174(2):555-9.
doi: 10.2214/ajr.174.2.1740555.

MR imaging of the pituitary gland in children and young adults with congenital combined pituitary hormone deficiency associated with PROP1 mutations

O Fofanova  1 , N Takamura, E Kinoshita, A Vorontsov, V Vladimirova, I Dedov, V Peterkova, S Yamashita
Affiliations

MR imaging of the pituitary gland in children and young adults with congenital combined pituitary hormone deficiency associated with PROP1 mutations

O Fofanova et al. AJR Am J Roentgenol. 2000 Feb.

Abstract

Objective: The aim of this study was to clarify the relationship between morphologic changes of the pituitary gland and the genotype of Prophet of Pit-1 (PROP1), a newly discovered gene responsible for congenital combined pituitary hormone deficiency, in a series of eight humans with this disorder.

Conclusion: Congenital hypoplasia of the anterior pituitary gland is the most common MR imaging finding in patients with combined pituitary hormone deficiency. Our findings suggest a crucial role for PROP1 in pituitary organogenesis as well as anterior pituitary cell differentiation.

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