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. 1976 Jul;73(7):2266-9.
doi: 10.1073/pnas.73.7.2266.

Deposition of histone onto the replicating chromosome: newly synthesized histone is not found near the replication fork

V Jackson, D Granner, R Chalkley

Deposition of histone onto the replicating chromosome: newly synthesized histone is not found near the replication fork

V Jackson et al. Proc Natl Acad Sci U S A. 1976 Jul.

Abstract

We have studied the site of deposition of newly synthesized histone. It appears to be randomly distributed over the chromosomal material and does not become associated specifically with immediately post-replicational DNA, nor is it deposited in discrete continuous regions distal to the sites of DNA synthesis. The newly synthesized DNA, however, rapidly acquires a complement of chromosomal proteins; presumably, preexisting histones must migrate to become associated with post-replicational DNA.

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References

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