Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Jul;73(7):2419-23.
doi: 10.1073/pnas.73.7.2419.

Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia

J F Remsen, P A Cerutti

Deficiency of gamma-ray excision repair in skin fibroblasts from patients with Fanconi's anemia

J F Remsen et al. Proc Natl Acad Sci U S A. 1976 Jul.

Abstract

The capacity of preparations of skin fibroblasts from normal individuals and patients with Fanconi's anemia to excise gamma-ray products of the 5,6-dihydroxydihydrothymine type from exogenous DNA was investigated. The excision capacity of whole-cell homogenates of fibroblasts from two of four patients with Fanconi's anemia was substantially below normal. This repair deficiency was further pronounced in nuclear preparations from cells of the same two patients.

PubMed Disclaimer

References

    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Nat New Biol. 1973 Jul 18;244(133):67-9 - PubMed
    1. Cancer Res. 1973 Aug;33(8):1829-36 - PubMed
    1. Biochim Biophys Acta. 1975 May 16;390(3):285-97 - PubMed
    1. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3532-6 - PubMed

Publication types

LinkOut - more resources