Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Jul;73(7):2515-9.
doi: 10.1073/pnas.73.7.2515.

Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor

R Simantov, S H Snyder

Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor

R Simantov et al. Proc Natl Acad Sci U S A. 1976 Jul.

Abstract

A substance that competes for opiate receptor binding has been isolated from calf brain and identified as two pentapeptides, H-Tyr-Gly-Gly-Phe-Met-OH (methionine enkephalin) and H-Tyr-Gly-Gly-Phe-Leu-OH (leucine enkephalin), with about four times more leucine enkephalin than methionine enkephalin. Sodium and manganese effects on opiate receptor interactions show that both peptides are agonists, whereas leucine enkephalin may be a "purer" agonist than methionine enkephalin.

PubMed Disclaimer

References

    1. Life Sci. 1976 Apr 15;18(8):781-7 - PubMed
    1. Proc Natl Acad Sci U S A. 1973 Jul;70(7):1947-9 - PubMed
    1. Life Sci. 1975 Jun 15;16(12):1777-82 - PubMed
    1. J Biol Chem. 1971 May 10;246(9):2842-8 - PubMed
    1. Nature. 1965 Dec 11;208(5015):1093-4 - PubMed

Publication types

LinkOut - more resources