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. 1999;46(3-4):163-6.
doi: 10.2739/kurumemedj.46.163.

An in vitro chemosensitivity test for colorectal cancer using collagen-gel droplet embedded cultures

Y Araki  1 , H Isomoto, A Matsumoto, A Kaibara, M Yasunaga, K Hayashi, H Yatsugi, K Yamauchi
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Free article

An in vitro chemosensitivity test for colorectal cancer using collagen-gel droplet embedded cultures

Y Araki et al. Kurume Med J. 1999.
Free article

Abstract

This study evaluated in vitro assay for chemosensitivity test using a collagen-gel droplet embedded culture drug sensitivity test (CD-DST) for colorectal cancer. CD-DST was performed in 24 patients with Dukes B, C colorectal cancer. Primary cultures of tumor cell samples from 87.5% (21/24) patients with colorectal cancer were successful. The efficacy rates assessed by CD-DST of five anticancer drugs evaluated were: 60.4% for adriamycin, 58.9% for etoposide, 56.7% for cisplatin, 53.4% for 5-fluorouracil, for 31.1% for mitomycin C, and 9.5% for vindesine. The present study demonstrated the clinical usefulness of CD-DST in evaluating the response to chemotherapy in colorectal cancer.

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