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Review
. 2000 Feb;8(2):74-7.
doi: 10.1016/s0966-842x(99)01669-8.

The causes and consequences of genetic variation in dengue virus

E C Holmes  1 , S S Burch
Affiliations
Review

The causes and consequences of genetic variation in dengue virus

E C Holmes et al. Trends Microbiol. 2000 Feb.

Abstract

Despite the fact that dengue is one of the most prevalent viral infections of humans, the mechanisms responsible for its pathogenesis remain uncertain. Evolutionary studies of dengue virus have revealed that its genetic diversity is increasing. This, coupled with evidence that viral strains could naturally differ in virulence, suggests that in the future we might be exposed to viruses with an expanded range of pathogenic properties.

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Comment in

  • Measuring virulence without a target.
    Bielefeldt-Ohmann H. Bielefeldt-Ohmann H. Trends Microbiol. 2000 Jun;8(6):265-6. doi: 10.1016/s0966-842x(00)01773-x. Trends Microbiol. 2000. PMID: 10838583 No abstract available.

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