[Isolation of acyclovir-resistant strains of herpes simplex virus from clinical material]
[Article in
Russian]
- PMID: 10665057
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[Isolation of acyclovir-resistant strains of herpes simplex virus from clinical material]
[Article in
Russian]
Vopr Virusol.
1999 Nov-Dec.
Abstract
A total of 115 strains of herpes simplex virus were isolated from clinical material collected in patients with genital herpes. The majority (93%) of isolated strains were sensitive to acyclovir: ID50 varied from 0.15 to 0.80 microgram/ml acyclovir. Eleven (7%) strains from 4 patients were resistant to acyclovir: ID50 was 30-125 times higher in comparison with the reference HSV-1 strain L2.
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