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Comparative Study
. 2000 Mar;74(5):2443-6.
doi: 10.1128/jvi.74.5.2443-2446.2000.

Elevated serum transforming growth factor beta1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM

J Xu  1 , A Ahmad, J F Jones, R Dolcetti, E Vaccher, U Prasad, J Menezes
Affiliations
Comparative Study

Elevated serum transforming growth factor beta1 levels in Epstein-Barr virus-associated diseases and their correlation with virus-specific immunoglobulin A (IgA) and IgM

J Xu et al. J Virol. 2000 Mar.

Abstract

Transforming growth factor beta (TGF-beta) is an immunosuppressive cytokine which can induce immunoglobulin A (IgA) switch and Epstein-Barr virus (EBV) replication in latently infected cells. Here we report elevated serum levels of TGF-beta in various EBV-associated diseases correlating positively with EBV-specific IgA titers and negatively with IgM titers, suggesting a role for this cytokine in the pathogenesis of these diseases.

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