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. 1976 Aug;73(8):2757-61.
doi: 10.1073/pnas.73.8.2757.

Defective thymine dimer excision by cell-free extracts of xeroderma pigmentosum cells

K Mortelmans, E C Friedberg, H Slor, G Thomas, J E Cleaver

Defective thymine dimer excision by cell-free extracts of xeroderma pigmentosum cells

K Mortelmans et al. Proc Natl Acad Sci U S A. 1976 Aug.

Abstract

Crude extracts of normal human diploid fibroblasts and of human peripheral blood lymphocytes excise thymine dimers from purified ultraviolet-irradiated DNA, or from the DNA presumably present as chromatin in unfractionated cell-free preparations of cells that had been labeled with [3H]thymidine. Extracts of xeroderma pigmentosum cells from complementation groups A, C, and D also excise thymine dimers from purified DNA, but extracts of group A cells do not excise dimers from the DNA of radioactively labeled unfractionated cell-free preparations.

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References

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