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. 1976 Aug;73(8):2872-6.
doi: 10.1073/pnas.73.8.2872.

Experimental myasthenia in Balb/c mice immunized with rat acetylcholine receptor from rat denervated muscle

D A Granato, B W Fulpius, J F Moody

Experimental myasthenia in Balb/c mice immunized with rat acetylcholine receptor from rat denervated muscle

D A Granato et al. Proc Natl Acad Sci U S A. 1976 Aug.

Abstract

A new model of an autoimmune disease of the neuromuscular junction was obtained by injection of acetylcholine receptor purified from rat denervated muscles into Balb/c mice. Anti-rat, then anti-mouse acetylcholine receptor antibodies, appear in mouse serum during the immunization procedure. Electrophysiological investigations performed on immunized mice reveal a neuromuscular block similar to that found in myasthenia gravis. Not a single mouse with objective signs of muscular weakness was lacking anti-mouse acetylcholine receptor antibodies but no correlation was found between their level and the severity of the disease.

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References

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