Thinking about vaginal microbicide testing
- PMID: 10667178
- PMCID: PMC1446143
- DOI: 10.2105/ajph.90.2.188
Thinking about vaginal microbicide testing
Abstract
A vaginal microbicide could slow the spread of HIV. To date, volunteers in placebo-controlled trials of candidate microbicides have been counseled to use condoms. This does not reduce the number of volunteers exposed to possible risk, but it shifts the allotment of risk from those conducting the trial to those women who may be least able to make autonomous decisions. Alternative ways of meeting the obligation to offer volunteers active benefits are explored. Counseling the use of condoms prolongs clinical trials and could cause tens of thousands of otherwise avoidable deaths.
Comment in
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Condom promotion in microbicide trials.Am J Public Health. 2000 Jul;90(7):1153-4; author reply 1156. doi: 10.2105/ajph.90.7.1153. Am J Public Health. 2000. PMID: 10897199 Free PMC article. No abstract available.
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Condom counseling in microbicide testing: a right of choice.Am J Public Health. 2000 Jul;90(7):1154; author reply 1156. doi: 10.2105/ajph.90.7.1154b. Am J Public Health. 2000. PMID: 10897200 Free PMC article. No abstract available.
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Ethics require the inclusion of condoms and counseling in anti-HIV microbicide trials.Am J Public Health. 2000 Jul;90(7):1154-5; author reply 1156. doi: 10.2105/ajph.90.7.1154a. Am J Public Health. 2000. PMID: 10897201 Free PMC article. No abstract available.
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Microbicide research and "the investigator's dilemma".Am J Public Health. 2000 Jul;90(7):1155; author reply 1156. doi: 10.2105/ajph.90.7.1155b. Am J Public Health. 2000. PMID: 10897202 Free PMC article. No abstract available.
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Further thoughts about vaginal microbicide testing.Am J Public Health. 2000 Jul;90(7):1155-6. doi: 10.2105/ajph.90.7.1155a. Am J Public Health. 2000. PMID: 10897203 Free PMC article. No abstract available.
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