Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999:469:455-60.
doi: 10.1007/978-1-4615-4793-8_67.

12-Lipoxygenase products increase monocyte:endothelial interactions

C C Hedrick  1 , M D Kim, R D Natarajan, J L Nadler
Affiliations

12-Lipoxygenase products increase monocyte:endothelial interactions

C C Hedrick et al. Adv Exp Med Biol. 1999.

Abstract

In summary, we suggest that hyperglycemia causes upregulation of 12-lipoxygenase activity. The increased production of 12-LO products, 12(S) and 15(S)-HETE, activates monocyte integrins which result in enhanced adhesion of monocytes to endothelium. The binding of monocytes to endothelium is a key early event in development of atherosclerosis. Upregulation of this process by vascular cells exposed to chronic elevations in glucose may be one explanation for the accelerated atherosclerosis observed in patients with Type 2 diabetes.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources